Duobrii vs. Enstilar for Plaque Psoriasis: Important Differences and Potential Risks.

Key takeaways

Duobrii (halobetasol/tazarotene) and Taclonex (calcipotriene/betamethasone) are both topical treatments for plaque psoriasis, but they have some key differences. Duobrii combines a corticosteroid (halobetasol) and a retinoid (tazarotene), while Taclonex combines a corticosteroid (betamethasone) and a vitamin D analog (calcipotriene). Duobrii is only available as a brand-name lotion, which can be expensive, whereas Taclonex is available in multiple forms, including some lower-cost generics. Duobrii is not recommended for long-term use due to potential hormone changes and skin reactions, and it is not safe during pregnancy. Taclonex, on the other hand, can cause high calcium levels and adrenal gland problems, and its foam form is flammable. Both medications can make your skin more sensitive to sunlight, so you should use sunscreen and protective clothing when outside.

Duobrii

(halobetasol / tazarotene)

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Enstilar

(calcipotriene / betamethasone)

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Summary for Duobrii

Prescription only

Duobrii is a combination medication that contains halobetasol (a corticosteroid) and tazarotene (a retinoid). It's a prescription topical lotion that's FDA-approved to treat plaque psoriasis in adults. The directions for using the medication are to apply a thin amount over the affected area(s) of skin once per day. But avoid putting on the face, groin, and underarms. Side effects aren't common, but can include skin rash and pain at the site of application. Duobrii is brand name only and not available as a generic.

Indications for Duobrii

Plaque psoriasis in adults

Pros and Cons for Duobrii

Pros

Applied once daily
Combines two medications into one lotion
Might see some improvements in as early as 2 weeks

Cons

For adults only; not studied in children
Not safe to use while pregnant or breastfeeding
Available as a brand-name product only

Common Side Effects for Duobrii

Skin rash (7%)
Pain where the medication was applied (3%)

Warnings for Duobrii

Harm to unborn babies
Altered stress hormone levels
Skin reactions and skin infections
Sun sensitivity and risk of sunburn
Cataracts and glaucoma

Summary for Enstilar

Prescription only

Enstilar (calcipotriene / betamethasone) is used to treat plaque psoriasis in people 12 years and older. It's a topical foam that contains two medications: calcipotriene (a form of vitamin D) and betamethasone (a corticosteroid). It's applied to the skin once a day, for up to 1 month. Side effects aren't common, but can include irritation and itching where you apply the medication. Enstilar (calcipotriene / betamethasone) is brand name only and not available as a generic.