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Omvoh vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Omvoh (mirikizumab) and Skyrizi (risankizumab) are both medications used to treat inflammatory conditions, and they work by blocking interleukin-23 (IL-23) to reduce inflammation. Omvoh is specifically FDA-approved for moderate-to-severe ulcerative colitis in adults, while Skyrizi is approved for that condition as well as moderate-to-severe plaque psoriasis, psoriatic arthritis, and Crohn's disease. Omvoh is administered initially as intravenous infusions for the first three doses, followed by monthly subcutaneous (under the skin) injections. In contrast, Skyrizi starts with intravenous infusions for ulcerative colitis and then switches to subcutaneous injections every 2 or 3 months. For subcutaneous injection forms, Omvoh is available as prefilled pens, while Skyrizi offers prefilled syringes, pens, and an On-Body Injector. Both medications can cause side effects like injection site reactions, joint pain, and increased risk of infections. Additionally, both medications require caution with live vaccines due to their immunosuppressive effects.

Omvoh

(mirikizumab)

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Skyrizi

(risankizumab)

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Summary for Omvoh

Prescription only

Omvoh (mirikizumab or mirikizumab-mrkz) helps treat ulcerative colitis and Crohn's disease in adults. It's a biologic known as an interleukin-23 antagonist. It works to help lower inflammation in the gut. When you first start, you'll get your first three doses as an infusion through the vein (IV) once a month at a clinic. After that, you (or your caregiver) can inject the rest of your doses under the skin every month at home. Side effects include joint pain and upper respiratory tract infections. Omvoh (mirikizumab) is available as a brand-name medication only.

Indications for Omvoh

Pros and Cons for Omvoh

Pros

  • Given once a month
  • Available as ready-to-inject prefilled pens and syringes after the first three infusions
  • Can inject maintenance doses at home with proper training
  • Can improve symptoms when other treatments haven't worked well

Cons

  • Injection only
  • Must get the first few doses as IV infusions from a healthcare professional
  • Can cause injection site reactions like redness, pain, and itchiness
  • Can raise your risk of getting sick more easily

Common Side Effects for Omvoh

Induction with IV infusions

Maintenance with under-the-skin injections

Warnings for Omvoh

  • Allergic reactions
  • Risk of infection
  • Liver injury
  • Avoid live vaccines

Summary for Skyrizi

Prescription only

Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

Indications for Skyrizi

Pros and Cons for Skyrizi

Pros

  • Given every 2 or 3 months after a couple of starter doses (depends on your condition)
  • Can give injections under the skin at home after you get trained

Cons

  • Must be given as an injection
  • Not approved for children

Common Side Effects for Skyrizi

Warnings for Skyrizi

  • Allergic reaction
  • Risk of infection
  • Rare case of liver injury
  • Caution when getting vaccines

Prices with our coupons for Omvoh vs. Skyrizi

Price Card Drug Icon
Omvoh1 carton / 2 pens of 100mg/ml
$11,523.06$13,576.62
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Price Card Drug Icon
Skyrizi1 package / 1 pen of 150mg/ml
$20,217.99-
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