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Skyrizi vs. Dupixent

Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

• Moderate-to-severe plaque psoriasis in adults
• Psoriatic arthritis in adults
• Moderate-to-severe Crohn's disease in adults
• Moderate-to-severe ulcerative colitis in adults

• Upper respiratory infections (13%)
• Headache (4%)
• Tiredness (3%)

• Allergic reaction
• Risk of infection
• Rare case of liver injury
• Caution when getting vaccines

Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

• Moderate-to-severe eczema - for people 6 months and older
• Moderate-to-severe asthma - add-on maintenance for people 6 years and older
• Long-term sinus congestion with nasal polyps - add-on maintenance for people 12 years and older
• Eosinophilic esophagitis - for people 1 year and older
• Prurigo nodularis (long-term itchy skin bumps) - for adults
• Chronic obstructive pulmonary disease (COPD) - add-on maintenance for adults
• Long-term hives - for people 2 years and older
• Bullous pemphigoid (blisters on the skin) - for adults
• Allergic fungal rhinosinusitis (sinus swelling due to fungi) - for people 6 years and older

• Injection site reaction (e.g., pain, swelling, bruising; 10%)
• Eye redness or eye inflammation (10%)
• Cold sores (4%)

• Allergic reactions
• Eye inflammation
• Other inflammation in the body
• Risk of worsening of breathing problems in people with asthma or COPD
• Risk of psoriasis
• Joint pain and psoriatic arthritis
• Unknown effect in people with parasitic worm infections
• Interaction with vaccines