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Kesimpta vs. Mavenclad

Kesimpta (ofatumumab) is an injectable medication for adults with relapsing forms of multiple sclerosis (MS). It works as a monoclonal antibody to help lessen MS flare-ups that come and go. Kesimpta (ofatumumab) is injected under the skin. You can use the Kesimpta prefilled syringes or Sensoready Pens to inject. After the first 3 weekly injections, you inject the medication once a month. Some common side effects include a higher risk of infections, pain or swelling at the injection site, and headache.

• Relapsing forms of multiple sclerosis (MS), including relapsing-remitting MS, clinically isolated syndrome, and secondary progressive MS

• Upper respiratory tract infections (39%)
• Reactions related to the injection (e.g., fever, chills, tiredness; 21%)
• Headache (13%)
• Reaction at the injection site (e.g., pain, redness, swelling; 11%)
• Urinary tract infection (10%)

• Risk of infections
• Injection reactions
• Lower antibody levels
• Harm to an unborn baby

Mavenclad (cladribine) is an oral medication used to treat multiple sclerosis (MS) that flares up from time to time (relapsing forms of MS). It's not a first-choice medication because it can cause many serious side effects, but it might be an option for people who didn't have good results from other MS medications. You only have to take it a few days out of the year, but need to get regular lab work to check your health. It can be very expensive because it's brand only.

• Relapsing forms of multiple sclerosis (MS)

• Infections that affect the nose, throat, and upper airways (38%)
• Headache (25%)
• Low lymphocyte count (24%)
• Nausea (10%)
• Back pain (8%)
• Muscle and joint pain (7%)
• Trouble sleeping (6%)

• Cancer
• Harm to unborn babies
• Serious infections
• Blood problems
• Liver injury