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Eohilia vs. Dupixent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Budesonide (Eohilia) and dupilumab (Dupixent) are both used to treat eosinophilic esophagitis (EoE), but they belong to different medication classes. Budesonide is a corticosteroid, while dupilumab is a monoclonal antibody. Budesonide is taken orally as a suspension, typically twice a day, and is specifically FDA-approved for EoE in people aged 11 and older. Dupilumab, on the other hand, is given as a subcutaneous injection and is approved for EoE in adults and children as young as 1 year old. It's also approved for several other conditions, such as asthma, eczema, and chronic obstructive pulmonary disease (COPD). Budesonide can cause side effects like respiratory infections and fungal infections in the mouth, while dupilumab may lead to injection site reactions and eye inflammation. Budesonide interacts with medications like ritonavir and erythromycin, whereas live vaccines should be avoided with dupilumab. Neither medication is available as a generic.

Eohilia

(budesonide)

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Dupixent

(dupilumab)

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Summary for Eohilia

Prescription only

Eohilia (budesonide) is a corticosteroid that's FDA approved to treat eosinophilic esophagitis (EoE) in adults and children. The dosage is typically a packet taken by mouth twice daily on an empty stomach. Side effects include respiratory tract infection, oral thrush, and headache. It hasn't been shown to be safe and effective for longer than 12 weeks.

Indications for Eohilia

Pros and Cons for Eohilia

Pros

  • Works well to treat symptoms of eosinophilic esophagitis
  • Available as single-dose packets of cherry-flavored suspension
  • Packets are ready to use; no need for any mixing beforehand
  • Approved for children as young as 11 years old

Cons

  • Must take twice per day
  • Can't have food or drink when you take the medication or within 30 minutes of taking it
  • The full treatment course is 12 weeks
  • Can raise the risk for respiratory tract infections, such as sinus infection or the common cold

Common Side Effects for Eohilia

  • Respiratory tract infection (13%)
  • Fungal infection in the mouth, throat, or esophagus (8%)
  • Headache (5%)

Warnings for Eohilia

  • Changes in cortisol levels
  • Withdrawal after switching from a different steroid
  • Higher risk of infection
  • Erosive esophagitis (damage to the esophagus)
  • Delayed growth in children
  • Worsening of certain medical conditions

Summary for Dupixent

Prescription only

Dupixent (dupilumab) is an injection that helps treat certain inflammatory conditions. This includes eczema, asthma, and chronic obstructive pulmonary disease (COPD), among others. It's a biologic medication known as an interleukin antagonist that lowers inflammation. Dupixent (dupilumab) comes as prefilled pens and prefilled syringes. It's injected under the skin of the belly or thighs (or in the back of the upper arm with someone's help). The dosing schedule depends on the condition you have, your age, and your weight. It's injected either every week, every 2 weeks, or every 4 weeks. Side effects include injection site reactions and eye problems.

Indications for Dupixent

Pros and Cons for Dupixent

Pros

  • Taken every other week or monthly for most conditions
  • Approved for some children (specific age depends on the condition)
  • Available as prefilled pens (for people ages 2 years and older)
  • Available as prefilled syringes (for people ages 6 months and older)

Cons

  • Given as an injection under the skin
  • Not used for helping with asthma attacks
  • Can cause injection reactions, such as pain, bruising, and swelling
  • Unknown if it's safe or works well while pregnant or breastfeeding

Common Side Effects for Dupixent

  • Injection site reaction (e.g., pain, swelling, bruising; 10%)
  • Eye redness or eye inflammation (10%)
  • Cold sores (4%)

Warnings for Dupixent

  • Allergic reactions
  • Eye inflammation
  • Other inflammation in the body
  • Risk of worsening of breathing problems in people with asthma or COPD
  • Risk of psoriasis
  • Joint pain and psoriatic arthritis
  • Unknown effect in people with parasitic worm infections
  • Interaction with vaccines

Prices with our coupons for Eohilia vs. Dupixent

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Eohilia10 cartons / 60 stick packs of 2mg/10ml
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Dupixent2 cartons / 2 pens of 300mg/2ml
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