What is Praxbind (idarucizumab) used for?

Praxbind (idarucizumab) is a medication used to reverse the anticoagulant (blood-thinning) effects of [Pradaxa (dabigatran)](https://www.goodrx.com/pradaxa/what-is). It's used in people taking Pradaxa (dabigatran) regularly who need to have an emergency surgery or procedure done or who are having life-threatening or uncontrolled bleeding.

How much Praxbind (idarucizumab) will I receive, and how is it given?

The [total dose](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=c7400f8a-dcf4-a6df-6d07-983081b1bf34&type=display#section-2) of Praxbind (idarucizumab) is 5 grams injected through the vein (intravenous, IV) as a single dose. Each vial of Praxbind (idarucizumab) contains 2.5 grams of medication, meaning it takes two vials to give the full dose. Your provider will give you your full dose as either two consecutive (one after the other) infusions or as two consecutive, quick injections with a syringe.

Praxbind

Q: How does Praxbind (idarucizumab) work?

Praxbind (idarucizumab) is a reversal agent (antidote). It works by attaching to Pradaxa (dabigatran) to inactivate it. This prevents Pradaxa (dabigatran) from working in your body.

Q: Does Praxbind (idarucizumab) work to stop bleeding from other anticoagulants?

No, Praxbind (idarucizumab) is specifically used to reverse the effects of Pradaxa (dabigatran) only. There are [other reversal agents available for other anticoagulants](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963825/) that are commonly used today.

Q: What are the side effects of Praxbind (idarucizumab)?

Since Praxbind (idarucizumab) reverses the anticoagulant effect of Pradaxa (dabigatran), there's a risk for [blood clots](https://www.goodrx.com/conditions/deep-vein-thrombosis/what-causes-blood-clots). After receiving Praxbind (idarucizumab), your provider will determine whether you still need an [anticoagulant](https://www.goodrx.com/classes/anticoagulants) like Pradaxa (dabigatran) or not. If your provider says it's safe for you to continue taking Pradaxa (dabigatran), you'll likely start taking it again 24 hours after you receive Praxbind (idarucizumab). [Other side effects](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=c7400f8a-dcf4-a6df-6d07-983081b1bf34&type=display#section-6) of Praxbind (idarucizumab) include headache, constipation, and nausea.

idarucizumab

Used for Anticoagulant Reversal

Praxbind (idarucizumab) is a rescue medication used to reverse the effects of Pradaxa (dabigatran) for people who require emergent surgery or who have a life-threatening bleed. It's given by a trained healthcare provider as an injection through the vein.

Reviewed by:

Robert Chad Hakim, PharmD, BCCCP

Kristianne Hannemann, PharmD

Last reviewed on May 24, 2022

What is Praxbind (idarucizumab)?

Drug facts

Common Brands	Praxbind
Drug Class	Antidote
Controlled Substance Classification	Not a controlled medication
Generic Status	No lower-cost generic available
Availability	Prescription only

Common Brands

Praxbind

Drug Class

Antidote

Controlled Substance Classification

Not a controlled medication

Generic Status

No lower-cost generic available

Availability

Prescription only

Common questions about Praxbind

Praxbind is a medication used to reverse the anticoagulant (blood-thinning) effects of Pradaxa (dabigatran). It's used in people taking Pradaxa (dabigatran) regularly who need to have an emergency surgery or procedure done or who are having life-threatening or uncontrolled bleeding.

Praxbind is a reversal agent (antidote). It works by attaching to Pradaxa (dabigatran) to inactivate it. This prevents Pradaxa (dabigatran) from working in your body.

The total dose of Praxbind is 5 grams injected through the vein (intravenous, IV) as a single dose. Each vial of Praxbind contains 2.5 grams of medication, meaning it takes two vials to give the full dose. Your provider will give you your full dose as either two consecutive (one after the other) infusions or as two consecutive, quick injections with a syringe.

No, Praxbind is specifically used to reverse the effects of Pradaxa (dabigatran) only. There are other reversal agents available for other anticoagulants that are commonly used today.

Since Praxbind reverses the anticoagulant effect of Pradaxa (dabigatran), there's a risk for blood clots. After receiving Praxbind, your provider will determine whether you still need an anticoagulant like Pradaxa (dabigatran) or not. If your provider says it's safe for you to continue taking Pradaxa (dabigatran), you'll likely start taking it again 24 hours after you receive Praxbind. Other side effects of Praxbind include headache, constipation, and nausea.

Praxbind

What is Praxbind (idarucizumab)?

Drug facts

Common questions about Praxbind

Praxbind (idarucizumab) dosage

Typical dosage for Praxbind (idarucizumab)

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Common questions about Praxbind

What is Praxbind (idarucizumab)?

Drug facts

Common questions about Praxbind

What is Praxbind used for?

How does Praxbind work?

How much Praxbind will I receive, and how is it given?

Does Praxbind work to stop bleeding from other anticoagulants?

What are the side effects of Praxbind?

Praxbind (idarucizumab) dosage

Typical dosage for Praxbind (idarucizumab)

Common questions about Praxbind

What is Praxbind used for?

How does Praxbind work?

How much Praxbind will I receive, and how is it given?

Does Praxbind work to stop bleeding from other anticoagulants?

What are the side effects of Praxbind?