Poly Hist Forte
Poly Hist Forte is a combination medication that contains doxylamine (an antihistamine) and phenylephrine (a decongestant). It's used for short-term relief of symptoms from allergies and the common cold, such as runny or stuffy nose, itchy or watery eyes, and sneezing. Poly Hist Forte (doxylamine / phenylephrine) is available over the counter as a tablet that's taken by mouth every 4 hours as needed. Side effects of this medication include sleepiness, dizziness, and dry mouth. Poly Hist Forte is brand name only.
What is Poly Hist Forte (doxylamine / phenylephrine)?
What is Poly Hist Forte (doxylamine / phenylephrine) used for?
Short-term relief of symptoms from allergies and the common cold:
- Stuffy nose
- Sinus congestion
- Runny nose
- Sneezing
- Itchy nose or throat
- Itchy, watery eyes
How Poly Hist Forte (doxylamine / phenylephrine) works
Poly Hist Forte is a combination of two medications that work together to relieve symptoms caused by allergies and the common cold.
- Doxylamine is a first-generation antihistamine. It blocks a natural substance in your body called histamine. By blocking histamine, doxylamine relieves runny or itchy nose, sneezing, and watery eyes.
- Phenylephrine is a decongestant. It tightens the blood vessels in your sinuses and nose to help with swelling and pressure, which will allow you to breathe better.
Drug facts
| Common Brands | Poly Hist Forte |
|---|---|
| Drug Class | Antihistamine / Decongestant |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Over-the-counter |
Side effects of Poly Hist Forte (doxylamine / phenylephrine)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness
- Restlessness
- Dizziness
- Dry mouth, nose, or throat
Less Common Side Effects
- Trouble urinating
- Nausea
- Vomiting
- Headache
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Pros and cons of Poly Hist Forte (doxylamine / phenylephrine)
Pros
- Can relieve multiple allergy and common cold symptoms
- Taken by mouth
- Might be an option for children as young as 6 years old
Cons
- Might need to take as often as every 4 hours for symptom relief
- Can't adjust the dose of a single medication in this combination
- Available as a brand-name medication only
Pharmacist tips for Poly Hist Forte (doxylamine / phenylephrine)
- You can take Poly Hist Forte (doxylamine / phenylephrine) with or without food. Try taking the medication with food if it upsets your stomach to help lessen any stomach side effects.
- Doxylamine in Poly Hist Forte (doxylamine / phenylephrine) can make you feel tired. This can affect your ability to think or react. Don't drive or do any task that needs a lot of focus until you know how the medication affects you. Also, don't drink alcohol while taking Poly Hist Forte because doing so can worsen tiredness and dizziness.
- While doxylamine usually makes adults sleepy, it's possible for children who use this medication to become overly excited or energetic. If this happens to your child, speak to your child's pediatrician.
- You can take Poly Hist Forte (doxylamine / phenylephrine) to temporarily relieve cold or allergy symptoms. But let your healthcare team know if your symptoms worsen or last longer than a week. Also tell them if you start to have a fever, because this is a sign that you might need more medical attention.
- Read the ingredients label on all the medications you're taking. Many over-the-counter cold and flu medications contain the same or very similar ingredients as those in Poly Hist Forte (doxylamine / phenylephrine). Taking more than one antihistamine or decongestant can raise your risk of severe side effects, including seizures, hallucinations (seeing things that aren't real), daytime sleepiness, and dizziness.
- Don't take Poly Hist Forte (doxylamine / phenylephrine) with a monoamine oxidase inhibitor (MAOI), such as selegiline. Combining phenylephrine and a MAOI medication can cause dangerously high blood pressure. If you've taken an MAOI in the past 2 weeks, contact your prescriber for other options to treat your symptoms.
- If you're pregnant, ask your obstetrician-gynecologist (OB-GYN) about safer alternatives for Poly Hist Forte (doxylamine / phenylephrine). While doxylamine can be taken during pregnancy, phenylephrine isn't recommended.
Risks and warnings for Poly Hist Forte (doxylamine / phenylephrine)
Poly Hist Forte (doxylamine / phenylephrine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Sleepiness
- Risk factors: Alcohol use | Taking other medications that cause sleepiness | Age 65 or older
Doxylamine (an ingredient in Poly Hist Forte (doxylamine / phenylephrine)) can make you very sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you're 65 years or older, drink alcohol while taking this medication, or take other medications that cause sleepiness (e.g., opioids, benzodiazepines, sleep medications). Don't drive or operate machinery until you know how Poly Hist Forte (doxylamine / phenylephrine) affects you.
Worsening of medical conditions
- Risk factors: Glaucoma | Heart disease or high blood pressure | Thyroid disease | High blood sugar (diabetes) | Breathing problems | Urinary problems
Poly Hist Forte (doxylamine / phenylephrine) might worsen certain medical conditions. This medication might not be appropriate for you if you have certain medical conditions, such as glaucoma, high blood pressure, breathing problems, and urinary problems. This medication also might not be safe if you're taking certain medications, such as opioids, or other antihistamines and decongestants. Before taking Poly Hist Forte (doxylamine / phenylephrine), let your healthcare professional know about what other medical conditions you have and ask if this medication is safe for you.
Accidental overdose
Poly Hist Forte (doxylamine / phenylephrine) contains an antihistamine (diphenhydramine) and a decongestant (phenylephrine), which are in many other over-the-counter products. Taking more than one medication containing an antihistamine or decongestant can lead to an accidental overdose, which can be life-threatening.
To prevent an accidental overdose, read the medication box and package labels carefully so you're aware of the ingredients, age-cut offs, and maximum dosing of your particular product. If you're not sure, ask your pharmacist to help you check for medication interactions.
Some signs of taking too much medication can include agitation or other behavior changes or high blood pressure. If you or your loved one experiences an accidental overdose, get medical help as soon as possible.
Poly Hist Forte (doxylamine / phenylephrine) dosage
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 10.5mg/10mg | 30 tablets | $26.01 | $0.87 |
Typical dosage for Poly Hist Forte (doxylamine / phenylephrine)
Each tablet contains 10.5 mg of doxylamine and 10 mg of phenylephrine.
- Adults and children ages 12 years and older: The typical dose is 1 tablet by mouth every 4 hours. The maximum dose is 6 tablets within a 24-hour period.
- Children ages 6 to under 12 years old: The typical dose is half a tablet by mouth every 4 hours. The maximum dose is 3 tablets within a 24-hour period.
- Children under 6 years old: Ask your child's pediatrician.
How much does Poly Hist Forte (doxylamine / phenylephrine) cost?
$26.01
Poly Hist Forte (doxylamine / phenylephrine) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Poly Hist Forte (doxylamine / phenylephrine) will not be safe for you to take.
- Currently take or have taken a monoamine oxidase inhibitor (MAOI) in the last 2 weeks
What are alternatives to Poly Hist Forte (doxylamine / phenylephrine)?
Short-term relief of symptoms from allergies and the common cold:
