Question 1

What is Pedmark (sodium thiosulfate) used to treat?

Accepted Answer

Pedmark (sodium thiosulfate) is a cytoprotective agent (medication that protects your cells). It's used in children older than 1 month who are receiving anticancer treatment with [cisplatin](https://www.goodrx.com/cisplatin/what-is). Specifically, Pedmark (sodium thiosulfate) is used to protect your child from hearing loss, which is a side effect of cisplatin. Cisplatin can cause loss of hearing because it damages the hair cells in the ear that help your child hear. Pedmark (sodium thiosulfate) helps to lower the risk of hearing loss by counteracting the toxic effects of cisplatin on your child's normal hair cells in the ear.

Question 2

How is Pedmark (sodium thiosulfate) given?

Accepted Answer

Pedmark (sodium thiosulfate) is typically infused into the veins over 15 minutes by a healthcare provider. It's usually given to your child 6 hours after their last cisplatin infusion and 10 hours before the next one. The dose of Pedmark (sodium thiosulfate) depends on [body surface area](https://www.ncbi.nlm.nih.gov/books/NBK559005/) (BSA), which takes into account your child's weight and height. Your child's provider will calculate the right dose for them.

Question 3

What are some side effects of Pedmark (sodium thiosulfate)?

Accepted Answer

Nausea and vomiting are common side effects of Pedmark (sodium thiosulfate). Before your child receives their infusion, their provider will give them medications to help prevent nausea as an extra precaution.

Question 4

Can Pedmark (sodium thiosulfate) cause severe allergic reactions?

Accepted Answer

Pedmark (sodium thiosulfate) can cause serious allergic reactions. Let your child's provider know if your child is allergic to foods or medications with [sulphite additives](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017440/), such as dried fruits. During the infusion, your child's provider will watch for any signs and symptoms of a reaction, such as rash, hives, trouble breathing, and swelling of the lips, tongue, throat, or face. This is to make sure Pedmark (sodium thiosulfate) is safe for your child. If your child has a reaction, their provider will stop the infusion. They'll give your child some medications to help prevent an allergic response to Pedmark (sodium thiosulfate) before future infusions.

Question 5

Are there any serious risks with Pedmark (sodium thiosulfate)?

Accepted Answer

Pedmark (sodium thiosulfate) can sometimes lead to high sodium levels and low potassium levels in the body. [High sodium levels](https://www.goodrx.com/health-topic/electrolyte/high-sodium-levels) can cause thirst, muscle weakness or spasms, restlessness, and poor appetite. [Low potassium levels](https://www.goodrx.com/conditions/hypokalemia) can affect heart rhythm, causing the heart to beat irregularly. Before receiving Pedmark (sodium thiosulfate), your child's provider will need to check your child's blood work to make sure this medication is safe for them. They will also watch for symptoms that include changes in heart beat, tiredness, high blood pressure, or muscle spasms during the infusion in case they need to stop the medication temporarily.

Question 6

What's the difference between Pedmark (sodium thiosulfate) and generic sodium thiosulfate?

Accepted Answer

Pedmark (sodium thiosulfate) and generic sodium thiosulfate aren't the same. The two medications aren't interchangeable. Pedmark (sodium thiosulfate) has a [unique formulation](https://investors.fennecpharma.com/news-releases/news-release-details/fennec-pharmaceuticals-announces-fda-approval-pedmarkr-sodium) of sodium thiosulfate that's used to lower the risk of hearing problems in children receiving cisplatin. On the other hand, [generic sodium thiosulfate injection](https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=82f55408-2de9-463d-85e8-b39c3b259f0b&type=display) is used as an antidote with sodium nitrite to stop [cyanide poisoning](https://emergency.cdc.gov/agent/cyanide/basics/facts.asp). If you've questions on the differences between Pedmark (sodium thiosulfate) and generic sodium thiosulfate, talk to your child's provider.

Pedmark

What is Pedmark (sodium thiosulfate)?

What is Pedmark (sodium thiosulfate) used for?

Are you looking for information on cisplatin, Ethyol (amifostine), or mesna (Mesnex) instead?

Drug facts

Common questions about Pedmark

Pedmark (sodium thiosulfate) dosage

Typical dosage for Pedmark (sodium thiosulfate)

Pedmark (sodium thiosulfate) images

Good news for your inbox

Common questions about Pedmark

What is Pedmark (sodium thiosulfate)?

What is Pedmark (sodium thiosulfate) used for?

Are you looking for information on cisplatin, Ethyol (amifostine), or mesna (Mesnex) instead?

Drug facts

Common questions about Pedmark

What is Pedmark used to treat?

How is Pedmark given?

What are some side effects of Pedmark?

Can Pedmark cause severe allergic reactions?

Are there any serious risks with Pedmark?

What's the difference between Pedmark and generic sodium thiosulfate?

Pedmark (sodium thiosulfate) dosage

Typical dosage for Pedmark (sodium thiosulfate)

Pedmark (sodium thiosulfate) images

Common questions about Pedmark

What is Pedmark used to treat?

How is Pedmark given?

What are some side effects of Pedmark?

Can Pedmark cause severe allergic reactions?

Are there any serious risks with Pedmark?

What's the difference between Pedmark and generic sodium thiosulfate?