dexchlorpheniramine
Dexchlorpheniramine maleate, also known as brand name RyClora, is a first-generation antihistamine. It's prescribed for adults and children ages 2 years and older to treat symptoms of allergy or allergic reaction, like rash, itching, and sneezing. This medication works by blocking the effects of a chemical in the body called histamine. Dexchlorpheniramine (RyClora) comes as a cherry-flavored liquid that you take by mouth every 4 to 6 hours. It can cause side effects such as sleepiness, dizziness, and dry mouth.
What is Dexchlorpheniramine (RyClora)?
What is Dexchlorpheniramine (RyClora) used for?
- Seasonal and year-round allergies
- Eye inflammation from airborne allergens or food
- Vasomotor (non-allergic) rhinitis
- Mild skin symptoms of hives and angioedema
- Dermatographism (condition with raised welts or hives caused by light scratching or pressure)
- Severe allergic reaction when used together with epinephrine
- Allergic reactions to blood or plasma products
How Dexchlorpheniramine (RyClora) works
Dexchlorpheniramine (RyClora) is a first-generation antihistamine. It blocks histamine, a natural chemical in your body that normally causes allergy symptoms. By blocking histamine, dexchlorpheniramine (RyClora) helps relieve allergy symptoms, such as runny nose, sneezing, and watery eyes.
Drug facts
| Common Brands | RyClora |
|---|---|
| Drug Class | Antihistamine |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Dexchlorpheniramine (RyClora)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness
- Dizziness
- Stomach upset
- Blurry vision
Less Common Side Effects
- Dry mouth
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Trouble urinating
- Double vision
- Weakness
Dexchlorpheniramine (RyClora) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction: rash, hives, itchiness, shortness of breath, chest tightness; swelling of lips, tongue, face, or eyes
The following Dexchlorpheniramine (RyClora) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common or rare
Less common or rare with azatadine, cetirizine, clemastine, cyproheptadine, desloratadine, dexchlorpheniramine, diphenhydramine, or loratadine
Abdominal or stomach pain
burning
chills
clay-colored stools or dark urine
difficulty swallowing
dizziness
fast or irregular heartbeat
headache
prickly sensations
puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
redness of skin
seizures
shortness of breath
skin rash
swelling
tightness in chest
tingling
unusual tiredness or weakness
Check with your doctor as soon as possible if any of the following side effects occur:
Symptoms of overdose
Clumsiness or unsteadiness
convulsions (seizures)
drowsiness (severe)
dryness of mouth, nose, or throat (severe)
feeling faint
flushing or redness of face
hallucinations (seeing, hearing, or feeling things that are not there)
shortness of breath or troubled breathing
trouble in sleeping
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Drowsiness
dry mouth, nose, or throat
gastrointestinal upset, stomach pain, or nausea
headache
increased appetite and weight gain
thickening of mucus
Less common or rare
Acid or sour stomach
belching
blurred vision or any change in vision
body aches or pain
clumsiness or unsteadiness
confusion (not with diphenhydramine)
congestion
difficult or painful urination
difficulty in moving
difficult or painful menstruation
dizziness (not with brompheniramine or hydroxyzine)
drowsiness (with high doses of desloratadine and loratadine)
dryness of mouth, nose, or throat
early menstruation
fast heartbeat
hoarseness
increased sensitivity of skin to sun
increased sweating
indigestion
loss of appetite
joint pain
muscle aching or cramping
muscle pains or stiffness
nightmares (not with azatadine, chlorpheniramine, cyproheptadine, desloratadine, hydroxyzine, or loratadine)
ringing or buzzing in ears
skin rash
swollen joints
stomach discomfort, upset or pain
tender swollen glands in neck
unusual excitement, nervousness, restlessness, or irritability
vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Pros and cons of Dexchlorpheniramine (RyClora)
Pros
- Treats many symptoms of allergies and allergic reactions
- Oral solution; potential option for people who can't swallow pills
- Can be taken by children as young as 2 years old
Cons
- Requires a prescription
- Might need to take every 4 hours
- Can worsen certain medical conditions, such as glaucoma or urinary problems
Pharmacist tips for Dexchlorpheniramine (RyClora)
- Use a medication dosing cup or oral syringe to measure the dose of dexchlorpheniramine (RyClora). If you need one, ask your pharmacy. Avoid household spoons because they might not be accurate and could lead you to take the wrong dose.
- Dexchlorpheniramine (RyClora) can make you sleepy, dizzy, and lose your balance. Don't drive until you know how this medication affects you. Also, avoid drinking alcohol because it can worsen these side effects.
- Dexchlorpheniramine (RyClora) can interact with other medications, such as monoamine oxidase inhibitors (MAOIs) (e.g., selegiline, phenelzine, tranylcypromine (Parnate)) and other medications that make you sleepy. Tell your care team about all the medications you take before starting dexchlorpheniramine (RyClora).
- Don't take other antihistamines while taking dexchlorpheniramine (RyClora). Many over-the-counter (OTC) products contain antihistamines, and taking more than one can raise your risk of antihistamine overdose, which can lead to serious side effects like heart problems, seizures, or even death.
- Store dexchlorpheniramine (RyClora) at room temperature up and away from children and pets. That way, they're less likely to reach it and accidentally take the medication. If you think your child accidentally took the medication, call a Poison Control Center right away at 1-800-222-1222.
Risks and warnings for Dexchlorpheniramine (RyClora)
Dexchlorpheniramine (RyClora) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Accidentally taking too many antihistamines
Accidentally taking too many antihistamines can be very dangerous, potentially leading to hallucinations, seizures, or even death. The risk is higher for children. Because dexchlorpheniramine (and other antihistamines) can be found in many over-the-counter cold and flu medications, it's important to check the labels of your medications to make sure you're not taking more than one antihistamine at a time.
Sleepiness
- Risk factors: Alcohol | Taking other medications that cause sleepiness | Older adults
Dexchlorpheniramine (RyClora) can make you sleepy, which can affect your ability to focus, think, or react. This side effect is more likely to happen or be more intense if you're an older adult, drink alcohol while taking dexchlorpheniramine (RyClora), or take other medications that cause sleepiness (e.g., opioids, benzodiazepines). Don't drive or operate machinery until you know how this medication affects you. It's best to avoid alcohol while taking dexchlorpheniramine (RyClora). Talk to your prescriber about possible interactions with other medications and how to manage them.
Worsening of medical conditions
Make sure your care team knows about all of your medical conditions before starting dexchlorpheniramine (RyClora). Though this medication is an antihistamine, it also has anticholinergic effects, which can worsen the symptoms of many conditions. These conditions include glaucoma, hyperthyroidism, heart disease, high blood pressure, stomach ulcers, trouble urinating, and an enlarged prostate.
Dexchlorpheniramine (RyClora) dosage
Typical dosage for Dexchlorpheniramine (RyClora)
Each 5 mL of RyClora contains 2 mg of dexchlorpheniramine.
- Age 12 years and up: The typical dose is 1 teaspoonful (5 mL) by mouth every 4 to 6 hours.
- Age 6 to under 12 years: The typical dose is one-half a teaspoonful (2.5 mL) by mouth every 4 to 6 hours.
- Age 2 to under 6 years: The typical dose is a quarter teaspoonful (1.25 mL) by mouth every 4 to 6 hours.
Interactions between Dexchlorpheniramine (RyClora) and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.
- Alfuzosin
- Amiodarone
- Amisulpride
- Amitriptyline
- Amprenavir
- Anagrelide
- Apomorphine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Artemether
- Asenapine
- Astemizole
- Atazanavir
- Azithromycin
- Bedaquiline
- Bepridil
- Brofaromine
- Bromopride
- Buprenorphine
- Buserelin
- Calcium Oxybate
- Ceritinib
- Chloroquine
- Chlorpromazine
- Ciprofloxacin
- Cisapride
- Citalopram
- Clarithromycin
- Clofazimine
- Clomipramine
- Clorgyline
- Clozapine
- Crizotinib
- Cyclobenzaprine
- Dabrafenib
- Darunavir
- Dasatinib
- Degarelix
- Delamanid
- Delavirdine
- Desipramine
- Deslorelin
- Deutetrabenazine
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxepin
- Dronedarone
- Droperidol
- Ebastine
- Efavirenz
- Encorafenib
- Entrectinib
- Eribulin
- Erythromycin
- Escitalopram
- Famotidine
- Felbamate
- Fingolimod
- Flecainide
- Fluconazole
- Fluoxetine
- Fluvoxamine
- Formoterol
- Foscarnet
- Fosphenytoin
- Furazolidone
- Galantamine
- Gatifloxacin
- Gemifloxacin
- Glasdegib
- Gonadorelin
- Goserelin
- Granisetron
- Grepafloxacin
- Halofantrine
- Haloperidol
- Histrelin
- Hydroquinidine
- Hydroxychloroquine
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Indinavir
- Inotuzumab Ozogamicin
- Iproniazid
- Isocarboxazid
- Itraconazole
- Ivabradine
- Ivosidenib
- Ketoconazole
- Lapatinib
- Lazabemide
- Lenvatinib
- Leuprolide
- Levofloxacin
- Levomethadyl
- Linezolid
- Lofexidine
- Lopinavir
- Lumefantrine
- Macimorelin
- Magnesium Oxybate
- Mefloquine
- Mesoridazine
- Methadone
- Methotrimeprazine
- Methylene Blue
- Metronidazole
- Mibefradil
- Mifepristone
- Mirtazapine
- Mizolastine
- Moclobemide
- Moricizine
- Moxifloxacin
- Nafarelin
- Nefazodone
- Nelfinavir
- Nialamide
- Nilotinib
- Norfloxacin
- Octreotide
- Ofloxacin
- Olanzapine
- Ondansetron
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Paliperidone
- Panobinostat
- Papaverine
- Pargyline
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Perphenazine
- Phenelzine
- Pimavanserin
- Pimozide
- Pipamperone
- Piperaquine
- Pitolisant
- Ponesimod
- Posaconazole
- Potassium Oxybate
- Probucol
- Procainamide
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Protriptyline
- Quetiapine
- Quinidine
- Quinine
- Ranolazine
- Rasagiline
- Ribociclib
- Risperidone
- Ritonavir
- Safinamide
- Saquinavir
- Selegiline
- Selpercatinib
- Sertindole
- Sertraline
- Sevoflurane
- Sodium Oxybate
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Solifenacin
- Sorafenib
- Sotalol
- Sparfloxacin
- Sulpiride
- Sultopride
- Sunitinib
- Tacrolimus
- Tamoxifen
- Telaprevir
- Telavancin
- Telithromycin
- Terfenadine
- Tetrabenazine
- Thioridazine
- Tipranavir
- Toloxatone
- Tolterodine
- Toremifene
- Tranylcypromine
- Trazodone
- Triclabendazole
- Trimipramine
- Triptorelin
- Troleandomycin
- Vandetanib
- Vardenafil
- Vemurafenib
- Venlafaxine
- Vilanterol
- Vinflunine
- Voclosporin
- Voriconazole
- Vorinostat
- Ziprasidone
- Zolmitriptan
- Zotepine
- Zuclopenthixol
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acecainide
- Acepromazine
- Adenosine
- Ajmaline
- Alefacept
- Alfentanil
- Alfuzosin
- Almotriptan
- Alprazolam
- Amifampridine
- Amiodarone
- Amisulpride
- Amitriptyline
- Amobarbital
- Amoxapine
- Amphetamine
- Anagrelide
- Anileridine
- Apomorphine
- Aprindine
- Aripiprazole
- Aripiprazole Lauroxil
- Arsenic Trioxide
- Artemether
- Asenapine
- Astemizole
- Atazanavir
- Azimilide
- Azithromycin
- Baclofen
- Bedaquiline
- Benperidol
- Benzhydrocodone
- Benzphetamine
- Bretylium
- Bromazepam
- Bromopride
- Buprenorphine
- Bupropion
- Buserelin
- Buspirone
- Butabarbital
- Butorphanol
- Calcium Oxybate
- Cannabidiol
- Capmatinib
- Carbamazepine
- Carbinoxamine
- Carisoprodol
- Carphenazine
- Ceritinib
- Cetirizine
- Chloral Hydrate
- Chlordiazepoxide
- Chloroquine
- Chlorpromazine
- Chlorzoxazone
- Ciprofloxacin
- Citalopram
- Clarithromycin
- Clobazam
- Clofazimine
- Clomipramine
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Crizotinib
- Cyclobenzaprine
- Dabrafenib
- Dalfopristin
- Dantrolene
- Dasatinib
- Degarelix
- Delamanid
- Desipramine
- Deslorelin
- Desvenlafaxine
- Deutetrabenazine
- Dexmedetomidine
- Dextroamphetamine
- Diacetylmorphine
- Diazepam
- Dibenzepin
- Dichloralphenazone
- Difenoxin
- Digoxin
- Dihydrocodeine
- Diphenhydramine
- Diphenoxylate
- Disopyramide
- Dofetilide
- Dolasetron
- Domperidone
- Donepezil
- Doxepin
- Doxylamine
- Droperidol
- Duloxetine
- Ebastine
- Efavirenz
- Encainide
- Encorafenib
- Enflurane
- Entrectinib
- Epinephrine
- Eribulin
- Erythromycin
- Escitalopram
- Esketamine
- Estazolam
- Eszopiclone
- Ethchlorvynol
- Ethopropazine
- Ethylmorphine
- Famotidine
- Felbamate
- Fenfluramine
- Fentanyl
- Fingolimod
- Flecainide
- Flibanserin
- Fluconazole
- Flunitrazepam
- Fluoxetine
- Fluphenazine
- Flurazepam
- Fluspirilene
- Formoterol
- Foscarnet
- Fosphenytoin
- Fospropofol
- Fostemsavir
- Gabapentin
- Gabapentin Enacarbil
- Galantamine
- Gatifloxacin
- Gemifloxacin
- Glasdegib
- Glucagon
- Glycopyrrolate
- Glycopyrronium Tosylate
- Gonadorelin
- Goserelin
- Granisetron
- Halazepam
- Halofantrine
- Haloperidol
- Halothane
- Hexobarbital
- Histrelin
- Hydrocodone
- Hydromorphone
- Hydroquinidine
- Hydroxychloroquine
- Hydroxytryptophan
- Hydroxyzine
- Ibutilide
- Iloperidone
- Imipramine
- Inotuzumab Ozogamicin
- Isoflurane
- Isradipine
- Itraconazole
- Ivabradine
- Ivosidenib
- Josamycin
- Ketamine
- Ketazolam
- Ketobemidone
- Ketoconazole
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Lenvatinib
- Leuprolide
- Levocetirizine
- Levofloxacin
- Levomilnacipran
- Levorphanol
- Lidoflazine
- Linezolid
- Lisdexamfetamine
- Lithium
- Lofexidine
- Lopinavir
- Lorazepam
- Lorcainide
- Lorcaserin
- Loxapine
- Lumefantrine
- Macimorelin
- Magnesium Oxybate
- Meclizine
- Mefloquine
- Melperone
- Meperidine
- Mephobarbital
- Meprobamate
- Meptazinol
- Mesoridazine
- Metaxalone
- Methacholine
- Methadone
- Methamphetamine
- Methdilazine
- Methocarbamol
- Methohexital
- Methotrimeprazine
- Methylene Blue
- Metoclopramide
- Metrizamide
- Metronidazole
- Midazolam
- Mifepristone
- Mirtazapine
- Mizolastine
- Molindone
- Moricizine
- Morphine
- Morphine Sulfate Liposome
- Moxifloxacin
- Nafarelin
- Nalbuphine
- Nelfinavir
- Nicomorphine
- Nilotinib
- Nitrazepam
- Nitrous Oxide
- Norfloxacin
- Nortriptyline
- Octreotide
- Ofloxacin
- Olanzapine
- Ondansetron
- Opium
- Opium Alkaloids
- Orphenadrine
- Osilodrostat
- Osimertinib
- Oxaliplatin
- Oxazepam
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Palonosetron
- Panobinostat
- Papaveretum
- Papaverine
- Paregoric
- Paroxetine
- Pasireotide
- Pazopanib
- Pentamidine
- Pentazocine
- Pentobarbital
- Perampanel
- Perazine
- Periciazine
- Perphenazine
- Phenobarbital
- Phenytoin
- Pimavanserin
- Pimozide
- Pipamperone
- Piperacetazine
- Pipotiazine
- Piritramide
- Pirmenol
- Pitolisant
- Ponesimod
- Porfimer
- Posaconazole
- Potassium Oxybate
- Prajmaline
- Prazepam
- Pregabalin
- Primidone
- Probucol
- Procainamide
- Procarbazine
- Prochlorperazine
- Promazine
- Promethazine
- Propafenone
- Propofol
- Propoxyphene
- Protriptyline
- Quazepam
- Quetiapine
- Quinidine
- Quinine
- Quinupristin
- Ramelteon
- Ranolazine
- Regadenoson
- Remifentanil
- Remimazolam
- Remoxipride
- Revefenacin
- Ribociclib
- Risperidone
- Ritonavir
- Roxithromycin
- Scopolamine
- Secobarbital
- Secretin Human
- Selpercatinib
- Sematilide
- Sertindole
- Sertraline
- Sevoflurane
- Simeprevir
- Siponimod
- Sodium Oxybate
- Sodium Phosphate
- Sodium Phosphate, Dibasic
- Sodium Phosphate, Monobasic
- Solifenacin
- Sorafenib
- Sotalol
- Spiramycin
- Sufentanil
- Sulfamethoxazole
- Sulpiride
- Sultopride
- Sunitinib
- Suvorexant
- Tacrolimus
- Tamoxifen
- Tapentadol
- Tedisamil
- Telaprevir
- Telavancin
- Telithromycin
- Temazepam
- Tetrabenazine
- Thiethylperazine
- Thiopental
- Thiopropazate
- Thioridazine
- Tilidine
- Tiotropium
- Tizanidine
- Tolonium Chloride
- Tolterodine
- Topiramate
- Toremifene
- Tramadol
- Trazodone
- Triazolam
- Triclabendazole
- Trifluoperazine
- Trifluperidol
- Triflupromazine
- Trimeprazine
- Trimethoprim
- Trimipramine
- Triptorelin
- Vandetanib
- Vardenafil
- Vemurafenib
- Venetoclax
- Venlafaxine
- Vilanterol
- Vilazodone
- Vinflunine
- Voclosporin
- Voriconazole
- Vorinostat
- Vortioxetine
- Zaleplon
- Zileuton
- Ziprasidone
- Zolpidem
- Zopiclone
- Zotepine
- Zuclopenthixol
Dexchlorpheniramine (RyClora) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Dexchlorpheniramine (RyClora) will not be safe for you to take.
- Newborn or premature infants
- Currently breastfeeding
- Treatment of lung problems, such as asthma
- Currently taking or have recently taken a monoamine oxidase inhibitor (MAOI)