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glycerin / naphazoline

Generic Clear Eyes Redness Relief
Used for Eye Inflammation

Clear Eyes Redness Relief is an over-the-counter (OTC) eye drop medication that contains two active ingredients: naphazoline (an alpha agonist) and glycerin (a lubricant). The eye drops relieve eye redness from minor irritations. They're also used to relieve dry eye and prevent further eye irritation. The typical dosage is 1 to 2 drops in the affected eye(s) up to 4 times a day. Although side effects aren't common, Clear Eyes Redness Relief can cause more eye redness if it's used for more than 3 days.

Note: There are many OTC products under the brand name "Clear Eyes" that might contain different ingredients. Read the package directions carefully before using.

Reviewed by:Last reviewed on May 21, 2024
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What is Clear Eyes Redness Relief?

What is Clear Eyes Redness Relief used for?

  • Short-term relief of eye symptoms, such as:
    • Eye redness due to minor eye irritations
    • Eye burning and irritation due to dry eye
  • Protection against further eye irritation

How Clear Eyes Redness Relief works

Clear Eyes Redness Relief is a combination of two active ingredients.

  • Naphazoline is an alpha agonist. It works by tightening the blood vessels in your eyes. This helps to relieve eye redness and irritation.
  • Glycerin is an eye lubricant. It helps keep the eye moist to prevent and relieve dry eye and eye irritation.

Drug facts

Common BrandsClear Eyes Redness Relief, Careone Maximum Strength Redness Relief
Drug Class Alpha agonist / Lubricant
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityOver-the-counter
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Side effects of Clear Eyes Redness Relief

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Side effects aren't common. See Other Side Effects.

Less Common Side Effects

  • Dilated pupils
  • Eye redness

Clear Eyes Redness Relief serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Vision changes
  • Eye pain
  • Worsening eye symptoms

Source: DailyMed

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Pros and cons of Clear Eyes Redness Relief

Pros

  • Available as a lower-cost generic medication
  • Combines two active ingredients into one eye drop for convenience; helps with dry eye and eye redness at the same time
  • Generally well-tolerated

Cons

  • Might need to use multiple times a day for relief
  • Only recommended for short-term relief of minor eye irritation
  • Might worsen eye redness if used for a long period of time
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Pharmacist tips for Clear Eyes Redness Relief

pharmacist
  • Only use Clear Eyes Redness Relief for your eyes.
  • Always wash your hands with soap and water before you use Clear Eyes Redness Relief eye drops. Also don't let the tip of the bottle touch the eye or other surfaces. This helps prevent germs from spreading to your eyes and lower your risk for eye infection.
  • Don't use Clear Eyes Redness Relief if the solution inside the bottle changes color or becomes cloudy. The eye drops might be contaminated with bacteria or other germs, which means it's not safe to use because of the risk for eye infection.
  • Make sure to take your contact lenses out before each time you use Clear Eyes Redness Relief eye drops. There's a preservative in the eye drops that can damage your contact lenses. Wait 10 to 15 minutes to put your contacts back in after you use the eye drops.
  • How to use Clear Eyes Redness Relief eye drops: Pull down your lower eyelid with one hand and hold the bottle upside down with the other. Tilt your head back and squeeze 1 drop into your affected eye. Then, close your eye and press your finger on the corner of your eye closest to your nose for 1 minute. Repeat these steps for your other eye, if needed.
  • Don't use Clear Eyes Redness Relief more often than what's directed on the package. Overusing this medication can raise the risk of more eye redness.
  • You can use Clear Eyes Redness Relief with other eye drop medications. But wait 3 to 5 minutes in between each eye drop medication to use the next medication. This gives enough time for each eye medication to get absorbed properly into your eye(s).
  • Clear Eyes Redness Relief can cause your pupils to dilate (or widen), but it's temporary. Stop using the eye drops and talk to an optometrist or ophthalmologist if you experience eye discomfort that doesn't go away or gets worse.
  • Stop using Clear Eyes Redness Relief and contact an optometrist or ophthalmologist if you have dry eye, eye irritation, or eye redness that gets worse or lasts for more than 3 days. Also stop using the eye drops and call an eye specialist if you have any eye pain or vision changes. These can be symptoms of a more serious eye condition that requires medical attention.
  • Keep Clear Eyes Redness Relief up and away and out of children's reach and sight. Always put the eye drops away every time you use it. This prevents children from accidentally swallowing any medication that's left out. Call a Poison Center at 1-800-222-1222 right away if a child might’ve accidentally swallowed the medication, even if you aren't completely sure.
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Risks and warnings for Clear Eyes Redness Relief

Clear Eyes Redness Relief can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Worsening of narrow-angle glaucoma

  • Risk factors: History of narrow-angle glaucoma | Overusing Clear Eyes Redness Relief eye drops

Clear Eyes Redness Relief can cause your pupil to widen for a brief period of time after you use the eye drops. This can sometimes lead to higher pressure in the eye. A rise in eye pressure can be a problem for people with narrow-angle glaucoma, which is a condition that blocks fluid from draining in your eye and causes high eye pressure. Ask your optometrist or ophthalmologist before you use Clear Eyes Redness Relief if you have high eye pressure or a history of glaucoma.

Overuse of Clear Eyes Redness Relief eye drops

When Clear Eyes Redness Relief is used for too long, it can cause rebound eye redness (your eyes become redder from overusing the eye drops). Don't use Clear Eyes Redness Relief for more than 3 days without speaking to your optometrist or primary care provider.

Use only in your eyes

Use Clear Eyes Redness Relief in your eyes only. Don’t place the eye drops into your nose, mouth, or ears. Call your Poison Control Center at 1-800-222-1222 right away if you think that your child might’ve accidentally swallowed the eye drop solution.

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Clear Eyes Redness Relief dosage

Typical dosage for Clear Eyes Redness Relief

Note: Many manufacturers make these eye drops under different brand names and in different strengths. Follow the instructions for your product or talk with your optometrist or pharmacist about how to use the eye drops.

The typical dose is 1 to 2 drops in the affected eye(s) up to 4 times a day.

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What are alternatives to Clear Eyes Redness Relief?

There are a number of medications that your doctor can prescribe in place of Clear Eyes Redness Relief. Compare a few possible alternatives below.
Clear Eyes Redness Relief
Used for:
  • Short-term relief of eye symptoms, such as:
    • Eye redness due to minor eye irritations
    • Eye burning and irritation due to dry eye
  • Protection against further eye irritation
Used for:
  • Dry eyes
  • Prevention of eye irritation
$7.20Lowest GoodRx priceView prices
Used for:
$37.23Lowest GoodRx priceView prices

References

Best studies we found

Ahn, J., et al. (2021). Binding affinity of benzalkonium chloride on contact lens surfaces and the effects on their physical properties. Colloids and Surfaces B: Biointerfaces.

American Academy of Allergy, Asthma & Immunology. (2024). Tips for administering eye drops.

Boyd, K. (2023). Redness-relieving eye drops. American Academy of Ophthalmology.

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